Thursday, October 3, 2013

TMA (Thrombotic Microangiopathy) Classification:


1) TMA associated with genetic/immune mediated abnormalities.
2) TTP associated with genetic or immune mediated ADAMTS 13 abormalities
3) Infectious Disease associated TMA (e.g. STEC-HUS, HIV)
4) Systemic Disease associated TMA ( e.g APLA, SLE, Malignant HTN, malignancy etc)
5) Pregnancy associated TMA (TTP, HELLP, post partum HUS)
6) Drug associated TMA ( CNI, clopidogrel, Anti-VEGF)
7) Transplant associated TMA.


Reference : Schmidtko J et al atypical hemolytic uremic syndrome and thrombotic microangiopathies: a focus on eculizumab. Am J Kidney Dis. 2013 Feb

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